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Authors have determined that NSAIDs including ibuprofen, indomethacin, and sulindac sulfide actually reduce production of the toxic ABeta42. The group also found that not all NSAIDs have this effect.
The work was carried out in tissue culture cells and in mice. Authors hope to start trials this year to find out whether these NSAIDs can cut ABeta42 in humans as well. The clinic is also trying to design compounds that resemble these NSAIDs but lack the ability to inhibit cyclooxygenase (cox), the principal mode of action of these compounds. Cox catalyzes the formation of molecules that help initiate inflammation.
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