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| PATENT EXAMPLES |
EXAMPLE X In vitro release of colchicine from a polyCPP:SA (30:70) film of 5 percent colchincine loading The in vitro release rate for a representative drug, colchicine (400 mw), from a polyCPP:SA (30:70) film is shown in FIG. 11 as the percent release over time (hr) at 37 degrees C. in buffered solutions having a pH of 2.0 and 7.4. The one mm thick fil was formed by solvent casting the 5 percent colchicine - polyCPP:SA (30:70) solution mixture. The results demonstrate that a controlled release occurs over a period of at least six days at pH 7.4 due to surface erosion of the polymer. Since the polymer is relatively stable at pH 2.0, there is no leaching of the colchicine out of the film due to other factors. |
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