| OBSERVATION'S |
D-Serine is synthesized in mammals brains & acts as a neu rotransmitter there (See Ref. Literature). Recently, few researchers have reported finding high levels of D-Serine in mammalian brains & have shown thet, in concert with glutamate, it activates the NMDA receptor. Activation of this receptor has been linked to memory & learning, as well as to nerve-cell death in stroke. Now researchers have shown that D-Serine is synthesized in the brain from its enantiomer, L-Serine. The team cloned & expressed SERINE RACEMASE the enzyme that performs the trick from mouse brain extracts. The team has now proven that D-Serine behaves as a neurotransmitter: When they incubate neurons contg D-Serine with an enzyme that destroys D-AA, activation of the NMDA receptor is greatly reduced. This finding suggests that molecules that inhibit serine racemase could pave the way for a new class of stroke drugs that act by vlocking production of D-Serine |
| UPDATE | 11.99 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
|
Want more information ? Interested in the hidden information ? Click here and do your request. |