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| PATENT EXAMPLES |
EXAMPLE 4 Reduction of the Symptoms of Feline Immunodeficiency Virus (FIV) A ten year old stray cat testing positive for FIV was treated by a veterinarian with a composition of the invention to determine whether the composition was effective against this virus. The animal was FeLV negative. One cc doses of Composition A prepared as in the previous examples were injected once per day intravenously for 8 days, after which the doses were switched to intramuscular injection for twenty-one days. After this initial dose regimen, the animal tested weakly positive for FIV using a combination FIV Ab/FeLV Ag test kit (Idexx Corp., Portland, Me.). Dosages were increased to 4 cc IM for three days, then intravenously for 15 days, after which the FIV test was positive. Treatment was reduced to 1 cc IV per day for one month, and was discontinued because the animal was not eating. The animal's appetite and demeanor improved within three days of the cessation of treatment. Treatment with 0.5 cc IV once a day was re-started 6 weeks later for a duration of one month, followed by a week without treatment before daily IV doses of 1 cc for three weeks, after which treatment was discontinued. The animal remained in visible good healthfor three more years after the treatments ceased. Thirty one months after the cessation of treatment, and again 9 months after that, complete blood counts did not reveal the luekopenia indicative of active FIV, nor had there been a history of opportunistic infections that one would expect if the virus were active. The animal was euthanized forty months after the cessation of treatment, due to a primary pulmonary adenocarcinoma. It is believed, since blood work never revealed the blood cell changes that are indicative of the disease, that the treatments with the composition of the invention were effective in preventing the active stages of FIV disease |
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