Main > NEUROLOGY. > Nitric Oxide > Synthase > Inhibitor > Screening Method

Product USA. J.

PATENT ASSIGNEE'S COUNTRY USA
UPDATE 06.99
PATENT ASSIGNEE This data is not available for free
PATENT CLAIMS Method of screening test compds for ability to decrease nNOS activity
- Contacting test compd with mixt of Protein Inhibitor of NO
(PIN-1) protein shown in SEQ ID NO:2 & first & second pro
teins comprising nNOS dimerization domain, wherein said
domains confer upon first & second proteins the ability to
bind to each other in the absence of PIN-1 & in absence of
test compd
- Measuring the amount of PIN-1 that is bound to first or se
cond protein, wherein a decrease in amount of first & se
cond protein bound to each other is indicative of ability of
test compd to decrease nNOS activity
PATENT PHOTOCOPY Available on request

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