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Making diabetes easier to stomach For some 75 percent of long-term sufferers of diabetes, a digestive condition known as gastroparesis causes regular discomfort--bloating, pain, even vomiting and dehydration--and can also interfere with insulin therapy by wreaking havoc on blood sugar levels. researchers have identified a lack of nitric oxide (NO) in key tissues--the same problem experienced in impotence. By combining insulin and sildenafil team has reversed gastroparesis in diabetic mice. "The study not only suggests a different approach to relieve gastroparesis, but it also offers ways for diabetics to keep their insulin and blood sugar levels on an even keel. With gastroparesis, a person's stomach fails to empty fully; food that remains in the digestive tract "can dramatically alter blood sugar levels," he says. "Yet being able to predict those levels is critical for diabetics on insulin. We think this work is useful, in part, because it could result in a way to keep digestion--and diabetes therapy--on track." While insulin alone can help reverse gastroparesis, it does not work as quickly nor relieve uncomfortable symptoms as effectively as sildenafil does, the researchers say. The team is now considering controlled trials of sildenafil in diabetic patients. -SD |
| UPDATE | 07.00 |
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