| STUDY |
Natural-product-like libraries are also being constructed by authors. The researchers vary the structure of scaffolds--central structures on which a variety of functional groups are added or modified--to create diverse libraries. Combinatorial chemists have more typically varied the functional-group "decorations" on scaffolds, rather than the scaffolds themselves, to generate libraries. Authors recently created a complex natural-product-like library by using a branched network of boronic ester annulation reactions on a varied set of aldehyde scaffolds. The boronic ester annulations produced a range of boronic acid intermediates that were subsequently modified into functionalized enones, trisubstituted allenes, enediols, tetraols, polycyclic heterocycles, and 1,3-diols
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