| DESCRIPTION |
an approach in which reagents or products are attached to solid supports such as polystyrene beads--is the most traditional form of phase trafficking. With solid-phase organic synthesis, it's easy to purify products by filtration, it's possible to do mix-and-split synthesis (a technique used to make very large libraries), excess reagents can be used to drive reactions to completion, and syntheses can be automated easily. However, relative to solution-phase synthesis, solid-phase synthesis often requires more development time (to adapt familiar solution-phase reactions to the solid-phase milieu) and additional linkage and cleavage steps are needed (to attach compounds to supports and later detach them). In addition, solid-phase reactions tend to be slower and product yields are more limited
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