| OBSERVATION'S |
PHASE TRAFFICKING. The most familiar way to synthesize most organic compounds is with classical solution-phase reactions, in which all the reagents, intermediates, and products remain in solution. "The beauty of pure solution-phase synthesis is the large lexicon of reactions one can perform. However, purifying products formed by solution synthesis can be difficult. "In solution-phase synthesis, typically an organic chemist will spend 10% of the time running a reaction and 90% of the time purifying it." That's why chemists are increasingly exploring phase trafficking, an alternative to conventional solution-phase synthesis in which synthesis and purification are carried out more or less simultaneously. In phase trafficking, reagents, by-products, or products are directed into a separate phase so the products can be isolated easily from the reaction mixture. Phase-trafficking methods "can be mixed and matched to enable high-throughput synthesis of a wide array of compounds
|