COMMENTS |
The nice thing about microwave heating is that you can do synthesis optimization really fast. "You can try, say, 20 different conditions for the same reaction in a matter of hours, rather than weeks. And then once you get the right synthesis method, you can use the same instrument and go kind of one at a time to build a library. Nobody yet has a parallel-synthesis microwave device that would let you run, say, 96 microwave-irradiated reactions all at once. That may come someday. But in the meanwhile, microwave ovens are so fast that you can run serial reactions and still get a lot done. It's a new and coming technology in combinatorial chemistry."
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