| TECHNOLOGY |
?lso appearing at ChemSpec for the first time this year was IEP GmbH, based in Wiesbaden, Germany. The company, formerly named Jülich Enzyme Products, specializes in process development for chiral synthesis based on biocatalysis, said its chief executive officer, Ortwin Ertl. Ertl touted a new group of reductases that convert a-ketoesters into a-hydroxyesters. The reaction requires an expensive cofactor, NADPH. To be viable commercially, the process must regenerate the cofactor. Systems developed by others usually have product/cofactor ratios of 1,000, whereas the IEP process has a turnover of more than 100,000, Ertl told C&EN. "Not only is it more economical, but it also tolerates a higher concentration of product, up to 25% compared with the usual 1% in other systems," he added. Products that have been made at an enantiomeric excess of at least 99% include both enantiomers of ethyl 4-chloro-3-hydroxybutyrate. Rütgers Chemicals is already making large-scale quantities of ethyl (S)-4-chloro-3-hydroxybutyrate based on the IEP process. The two companies are collaborating on other systems for enzymatic organic synthesis |
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