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Co also provides maps of protein-protein interactions discovered in yeast two-hybrid screens (http://pim.hybrigenics.com/pimriderlobby/PimRiderLobby.htm). Each interaction is evaluated and given a reliability score, ranging from A (a highly reliable interaction) through E (a probable artifact), so scientists can focus on the most important ones. The interacting domain of each protein is identified and mapped.
Knowing precisely which domain interacts is a good start for drug modeling studies. He noted that Co.`s researchers recently analyzed the interactions and functional relationships of proteins encoded by the genome of the gastrointestinal pathogen Helicobacter pylori and found that each H. pylori protein participates in 3.6 interactions on average.
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