| METHOD |
The blueprint of life could soon become the blueprint for small-molecule synthesis as well. Authors have used DNA to direct multistep small-molecule syntheses. In this method, a template DNA strand encodes the final product. Complementary DNA sequences ferry reagents to the growing molecule in a role analogous to transfer RNA. TEAM Gartner (from left), Liu, and Kanan use DNA to direct small-molecule synthesis. Photo by angela landrigan “Developing methods of translating DNA sequences into synthetic small molecules is a requirement for applying to these synthetic compounds some of the powerful processes that nature has used to evolve proteins and nucleic acids. The multistep syntheses required the team to devise linker and purification strategies for separating the reagent DNA from the product, in addition to a variety of new DNA-templated synthetic reactions. Authors are currently using these strategies to generate DNA-templated small-molecule libraries suitable for in vitro selections. |
| UPDATE | 08.02 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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