| METHOD |
In 1994, authors applied for an NIH grant to support what turned out to be the first complete prokaryotic genome sequence--that of Haemophilus influenzae, a bacterium that causes ear and respiratory tract infections. They proposed to do the sequencing by a totally untested technique--whole-genome shotgun sequencing, which "was described for the first time in our landmark publication on H. flu." |
| OBSERVATION'S |
Author points out that, in his group's Haemophilus paper, "there was this very controversial paragraph that said this is the method I believe will be used for sequencing the human genome. Everyone thought I was just crazy to be writing that. But when you understand the technique, you see that there is no theoretical block to its potential. I think the major sequencing labs didn't want it to work because they had a vested interest in what they were doing." |
| UPDATE | 08.02 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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