| SYNTHESIS |
The enzymes that synthesize peptidoglycan, the main component of bacterial cell walls, can be tricked into inserting chemically modified intermediates into these walls, a team of chemists has found. That permissiveness is key to a simple and versatile strategy for displaying compounds on the walls of living bacteria, expanding a synthetic strategy originated by Chi-Huey Wong and coworkers at Scripps Research Institute. The researchers are now attempting to use ketones within the cell wall structures to covalently attach antigens to the bacterial cell surface. |
| UPDATE | 08.02 |
| USES | If successful, the approach might lead to vaccines based on lactic acid bacteria that could be taken orally. In other experiments, they hope to attach residues to the ketone groups that can later be cross-linked into a sturdy polymer matrix surrounding the bacterium. Such semiartificial bacteria would be very useful in bioengineering production systems |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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