| MECHANISM OF ACTION | The drug is a chelator with a high binding capacity for zinc and some other metals--the same metals that help to aggregate amyloid peptides into plaques. So the strategy is to use the drug to compete with amyloid for the metal ions, and as a result break apart the amyloid plaques. "And in fact, if you treat transgenic mice which have amyloid deposits with clioquinol, it clears the plaques," he says. The drug may also inhibit A-mediated production of damaging H2O2 |
| UPDATE | 03.02 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
|
Want more information ? Interested in the hidden information ? Click here and do your request. |