| SYNTHESIS |
polyamide "chemobodies" have been synthesized by author. "Chemobody" refers to a chemically synthesized antibody-like molecule. Chemobodies are synthetic molecules that display multiple peptide subunits that can bind simultaneously to complementary structures. "We wish to exploit the enhanced avidity [multivalent affinity] offered by binding through two or more subunits simultaneously--multivalent binding--and the flexibility of synthetic chemistry to create molecules of high avidity and selectivity. "When several copies of the same peptide are present in a single multimeric molecule, avidities and bioactivities can be greatly enhanced over the affinity or activity of the monomeric peptide." Using oxime chemistry, author and coworkers have successfully attached up to eight peptides to a core molecule. To be able to bind through two or more peptide groups simultaneously, the units must be spaced at appropriate distances and the linking moiety must be flexible. The researchers synthesized a new class of polyamide chains that contain a variable but controllable number of monomer units and used them as flexible linkers to control spacing of ligands in their chemobodies. Each chemobody resembles a molecular octopus, with one copy of a peptide on the tip of each of several "tentacles" (polyamide linkers). Author hopes chemobodies will prove useful for potential diagnostic, therapeutic, and sensing applications |
| UPDATE | 10.00 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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