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It's a valuable addition to the armamentarium of how to end up with candidates for safety assessment that are orally bioavailable."
In pharmaceutical research, "we used to improve potency all we could, and very often we ended up with compounds that were very insoluble and not available orally. "But in the past 15 years, the industry has learned that you had better worry about oral bioavailability early on in the game. The more rules you have to guide you in that endeavor, the better off you are."
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