| SYNTHESIS |
Lithium aluminum hydride reacts with elemental selenium to yield LiAlHSeH, a new selenating reagent that could allow the easy preparation of a wide range of selenium-containing compounds. Such compounds are of interest as potential chemotherapeutic agents. prepare the selenating reagent and then, without isolating it, use the reagent to make compounds such as diacyl selenides in high yields in a one-pot reaction. Previous syntheses of diacyl selenides required many steps, the chemists note. They also report the synthesis of a variety of other compounds, including diacyl diselenides, glutaric selenoanhydride, -selenobutyrolactone, selenoamides, and the first N,N-dialkyl diselenocarbamates (shown).
|