| PATENT ASSIGNEE'S COUNTRY | USA |
| UPDATE | 08.99 |
| PATENT ASSIGNEE | This data is not available for free |
| PATENT CLAIMS |
Method of purifying CFTR protein having complex-type glyco sylation from a mammalian cell - Providing mammalian cell membrane fraction with which said complex-type glycosylated CFTR is an integral mem brane protein - Alkali-stripping > 60% of peripherally bound membrane protein from fraction - Contact. stripped fraction with buffered soln contg alpha lyso phosphatidylcholine detergent to solubilize > 80% of CFTR from membrane fractions without solubilizing > 50% of non- CFTR protein - Contact. solubilized CFTR with anti-CFTR MAb in presence of concn of alpha lysophosphatidylcholine detergent that permits specific interaction of CFTR to Ab - Dissociating Ab-CFTR complex in presence of cholate de tergent |
| PATENT PHOTOCOPY | Available on request |
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