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recently developed a dual-bait variation of the yeast two-hybrid system that analyzes two independent protein-protein interactions simultaneously. At the Proteomics conference, Ilya Serebriiskii, a research associate in author's group, explained that the dual-bait system excels at distinguishing specific from nonspecific interactions. For instance, it can be used to identify two discrete sets of interacting proteins against an extensive background population of nonspecifically interacting proteins.
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