| SYNTHESIS |
makes the aminotetralin and aminochroman by similar methods. For example, he alkylates 7-methoxy-2-tetralone with (R)--phenethylamine. The intermediate is an enamine, which he reduces to a single enantiomer amine with catecholborane (1,3,2-benzodioxaborole) over 10 hours at –70 °C. Hydrogenation cleaves the phenethyl group and frees the (S)-aminotetralin. |
| UPDATE | 07.01 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
|
Want more information ? Interested in the hidden information ? Click here and do your request. |