| STUDY |
Treatment with hormones including estrogen and testosterone is another potential AD therapy, but it's controversial. However, some other studies show no effect. FURTHER EVIDENCE for a connection between sex hormones and AD comes from a study Gandy conducted of men undergoing hormone suppression therapy for prostate cancer. Once the patients' testosterone and estrogen levels had declined, their plasma amyloid levels roughly doubled. |
| MECHANISM OF ACTION | He believes the hormones inhibit amyloid accumulation. And they may do that by activating phosphorylation of a secretase regulator that breaks APP into harmless fragments |
| OBSERVATION'S |
Testosterone, too, is being considered as a starting point to develop analogs lacking its association with aggressive behavior, he notes. |
| UPDATE | 03.02 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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