| STUDY |
Many epidemiological studies have indicated that estrogen replacement therapy in postmenopausal women is beneficial, cutting risk of developing AD by about half. However, some other studies show no effect. FURTHER EVIDENCE for a connection between sex hormones and AD comes from a study Gandy conducted of men undergoing hormone suppression therapy for prostate cancer. Once the patients' testosterone and estrogen levels had declined, their plasma amyloid levels roughly doubled. More data on estrogen's effects should begin to become available next year from rigorously controlled studies by investigators including Columbia University neurologist Mary Sano. |
| MECHANISM OF ACTION | He believes the hormones inhibit amyloid accumulation. And they may do that by activating phosphorylation of a secretase regulator that breaks APP into harmless fragments. Author demonstrated that estrogen can diminish Ab generation in cultured neurons |
| OBSERVATION'S | Author says pharmaceutical companies are trying to design selective estrogen receptor modulators that can duplicate the positive effects of estrogen while avoiding drawbacks such as cancer and venous thrombosis |
| UPDATE | 03.02 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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