| OBSERVATION'S |
The cost of a synthesis, known as "cost of goods" to those in the business, is an important consideration for process chemistry. Author uses a "back of the envelope" formula for determining a ballpark figure for a given synthesis. The sum of the
number of rings, functional groups, heteroatoms, stereocenters, and regiocenters multiplied by 100 gives a rough estimate of the target cost per kilogram when a process is fully scaled up and commercialized. Cost of goods includes cost of raw materials, manufacturing costs to make the drug, waste disposal, and licensing fees.
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