| STRUCTURE |
Thiazole-2-NH2-4-[C6H4-NHCO-CH2-N(CHMe-Ph)-CO-(4- Pyridyl)] |
| COMMENTS | One advantage it has over acyclovir is that it can be used less frequently. It is also more effective in cases where treatment has been delayed. Compd is more potent than acyclovir, which has limited bioavailability. Its potency is restricted by the fact that it must be phosphorylated by a viral enzyme before it can act on DNA polymerase. As many as one virus per 1000 may not have the needed enzyme & thus not be sensitive to acyclovir |
| FORMULATION | Oral |
| MECHANISM OF ACTION | Compd work by acting on 2 enzymes, helicase & primase, that are part of an enzyme complex HSV needs to untwist its double-stranded DNA to form single strands & then prime the strands for replication into new viral DNA. Different lines of evidence indicated that the helicase-primase complex is rate-limiting for HSV replication |
| UPDATE | 04.02 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
|
Want more information ? Interested in the hidden information ? Click here and do your request. |