| STUDY |
Author believes disease's symptoms through oxidative stress. He treated rats with very low levels of rotenone, 0.5 - 0,00005 times the usual doses employed in Parkinson's research. He found that rotenone caused degeneration of the nerve cells that produce dopamine in the substantia nigra. The rats developed inclusions in the subs tantia nigra that are fibrillar, but not identical to Lewy bodies, & the rats' movements - slow & rigid - resembled those of Parkinsons patients. "We think the rotenone was causing oxidative stress & increasing the production of alpha-synu clein" Subsequently the alpha-synuclein became insoluble & formed protofibrils" |
| UPDATE | 09.01 |
| USES | Rotenone is a natural compd derived from the roots of tropical plants. Used to kill nuisance fish in lakes, insects in gardens, & fleas & ticks in pets. Some foresters bathe in it after working in the woods |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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