| STUDY |
Researchers set out to determine whether they could produce a better animal model for disease. Such animals would have a generalized "defect" in Complex 1, a dehydrogenase in the mitochondrial electron transport chain. And their brains would contain protein aggregates called Lewy bodies that are characteristic of disease. The group infused rotenone, a natural prodt used as a pesticide, into the jugular vein in rats. Rotenone was chosen "because it's the biochemical standard for inhibiting Complex 1, & it's very lipophilic, so it crosses [cell] membranes" "But it was also of interest that rotenone was a known pesticide, & epidemiological studies have implicated pesticide exposure as risk factor for disease. Over time, the low doses of rotenone did produce disease's symptoms, accompanied by Lewy bodies & generalized deficiency of Complex 1 in the rats. The author acknowledges that the study doesn't provide "enough evidence that rotenone or any other specific pesticide is a culprit in disease. Moreover, "whatever people may ingest that may cause disease over a number of years, their risk is going to be modulated by their [genetic] ability to detoxify" the compds. But he insists that the findings warrant more epidemiological studies on the effects of pesticides |
| UPDATE | 11.00 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
|
Want more information ? Interested in the hidden information ? Click here and do your request. |