| SYNTHESIS |
Route finally decided on is a heterogeneous Diels-Alder reaction between butadiene & ethyl glyoxylate. The prodt is a racemic dihydropyrancarboxylate A protease hydrolyzes the unwanted (R)-ester. Further operations on the (S)- ester lead finally to a protected deriv of the required (S)-2-hydroxyethoxy-1,4- butane-diol. Protease used was cross-linked crystal version of protease supplied by Altus Biologics |
| UPDATE | 05.01 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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