| SYNTHESIS |
The new procedure makes it possible to add a CIS-ENAMIDE group to a structure that already contains delicate functional groups. Problem found was need to add near end of synthesis a cis-enamide to almost complete TMC-95 precursor Researchers solved problem, by using a ALPHA-SILYLALLYL AMINE reagent {R-CONH-CH[Si(Et)3]-CH=CH2}. The amine is attached via a amide bond to a protected TMC-95 precursor. After heating, the amide undergoes bond reorganization & the imidate prodt is then hydrolyzed to form the desired cis enamide moiety |
| UPDATE | 03.02 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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