| SYNTHESIS |
Process to make BETA-AMINO ACIDS. Such aminoacids have found use in making NONNATURAL PEPTIDES with pharmaceutical activity & RESIS TANCE to HYDROLYSIS The object is asymmetric hydrogenation of METHYL BETA-ACETAMINO CROTONATE. The problem is that the substrate exists as both E & Z isomers Past efforts have led to poor enantiomeric excesses owing to lack of enantio selectivity in the Z isomer. Researchers find that success comes with use of a polar solvent such as MeOH & LOW HYDROGEN PRESSURES. They get 98% ee with pure E isomer, 88% with pure Z isomer & 92% with mixt used as prepd without separating |
| UPDATE | 10.01 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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