| MECHANISM OF ACTION |
Lethal factor exerts its effect by recognizing a signaling molecule, the kinase MAPKK-2. This molecule uses a tail at its N-terminus to dock onto another kinase in the signaling pathway. Lethal factor clips this tail, cutting commu nication between the 2 kinases. Author says the crystal structure shows how lethal factor recognizes & cleaves the target peptide The work provides critical new insights into the mechanism of action of anthrax lethal factor” “A high-resolution map of lethal factor will greatly assist the development of potent inhibitors that may prove to be life- saving drugs” |
| UPDATE | 10.01 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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