| TECHNOLOGY |
Technology that may find use in cell-based gene therapy is the HUMAN AR TIFICIAL CHROMOSOME. These chromosomes have all the features of natural chromosomes, including a centromere, telomeres, & structural noncoding DNA. However, they contain only the genetic information that Co.’s scientists engineer into them. The artificial chromosomes reside in the nucleus beside the natural chromosomes. When the cell divides, the artificial chromosomes replicate just like natural chromosomes. Co. grows the artificial chromosomes from naturally occurring acrocentric chromosomes, which have their centromeres very close to one end, producing short & long arms. “We’re been able to identify a sequence that we refer to as the megareplicator”. “This means that when we target into it, it triggers a big amplification. The short arm begins to grow. A second centromere ultimately appears. Now you have a structure that has a long arm of the chromosome, then a centromere, then it has the new chromosome. It does not have any genetic information in it other than what we’ve targeted in there as part of the triggering process”. This dicentric chromosome is unstable, & when the cell divides, it breaks, leaving the original chromosome & the new artificial one. The artificial chromosome are large structures: 40-60 million base pairs long. Co has demonstrated information-carrying capacities of 1-1.5 million base pairs. “Our system allows you to start contemplating working with gene arrays multiple copies of a gene, or genomic sequences. It allows you to start contemplating putting on genes & coupling them to appropriate regulators. It allows you to really start thinking about being able to focus in on novel & complex proteins that might not otherwise be able to be produced in existing systems” |
| UPDATE | 11.01 |
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