| METHOD |
The 1st dynamic resolution of a racemate driven by a flurry of Michael & reverse-Michael additions has been reported. Researchers use a lipase to hydrolyze the (R)-enantiomer of a Pr oxazoline acetate thioester to the free acid. The (S)-thioester racemizes by continuous ring-opening reverse-Michael & Michael additions. The end result is con version of all of the thioester to (R)-acid. The researchers credit organic chemistry prof Dale G. Drueckhammer of the State University of NY., Stony Brook, with the idea to use a thioester to render alpha-protons more acidic in the process |
| UPDATE | 11.01 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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