| TECHNOLOGY |
Biosensor – using a QCM to detect viruses. They call their method “RUPTU RE event scanning” Authors attach ANTIBODIES to viruses on the surface of the QCM. Viruses in the sample then bind to the antibodies. The researchers make the QCM OSCILLATE at increasing amplitude by applying a alternating ELECTRIC field. When a critical amplitude is reached, the bond between the Ab & virus us broken. The QCM – a type of acoustic device – then acts as “MICROPHO NE”, converting the acoustic emission from the bond rupture to ELECTRIC SIGNAL. “In essence, we separate & detect in a single process”. “Because we scan up, shaking off the things thar are poorly attached first & then shaking off the things that are more strongly attached later, we discriminate between nonspe cific & specific adsorption”. They used the sensor to detect type 1 HERPES simplex virus The QCM method is nearly as sensitive as PCR, the primary method for detecting viruses “The advantages of our technique over PCR are that it’s direct & rapid, with potentially very little sample prepn.”. However, he notes there is a big difference between experiments in the lab & real clinical samples from people |
| UPDATE | 09.01 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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