| PATENT ASSIGNEE'S COUNTRY | USA |
| UPDATE | 10.99 |
| PATENT ASSIGNEE | Baystate Medical Center |
| PATENT CLAIMS |
In cells expressing the protein, wherein unmutated BRCA protein contains amino-terminus & carboxy-terminus regions & wherein mutated BRCA protein is typically a foreshortened protein from which carboxy-terminus regions are missing, wherein the method comprises - Prepg a first & second equal quantity of cells that express the BRCA protein, wherein the first & second equal quantity of cells are obtained from one test subject - Adm. quantity of first primary Ab capable of detecting or reacting with the amino-terminus regions of the BRCA protein to the first quantity of cells - Adm an equal quantity of a second primary Ab capable of detecting or reacting with the carboxy terminus regions of the BRCA protein to the second quantity of cells - Measuring Ab reactivity within first & second quantity of cells - Comparing the measured Ab reactivity within the first quantity of cells to the measured Ab reactivity within the second quantity of cells to determine the presence of mutated BRCA protein in first & second quantity of cells Wherein a difference between the measured Ab reactivity within the first quantity of cells & measured Ab reactivity within second quantity of cells indicates the presence of mutated BRCA protein in first & second quantity of cells |
| PATENT PHOTOCOPY | Available on request |
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