| PATENT ASSIGNEE'S COUNTRY | France |
| UPDATE | 06.00 |
| PATENT ASSIGNEE | Aventis Pharma SA |
| PATENT CLAIMS |
Process for the prepn of pearls of an active principle exhibi ting an indefinite crystallization point, wherein said pearls exhibit a prolonged release profile, comprising - Melting the active principle & a crystallization excipient to create a molten mixt - Introducing the mixt into feed receptacles of a prilling tower - Passing the mixt through a nozzle which is vibrated to form pearls & - Allowing the pearls to fall in the tower countercurrentwise to cold air, said cold air being at a first T which causes super cooling of said pearls Wherein the tower is provided with a fluidized bed proximate the bottom of the tower Wherein said fluidized bed is maintained at a second T that is higher than said first T, said second T being above the Tg of the active principle & below the T of onset of liquefaction of the excipient |
| PATENT PHOTOCOPY | Available on request |
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