| PATENT ASSIGNEE'S COUNTRY | USA |
| UPDATE | 05.00 |
| PATENT ASSIGNEE | This data is not available for free |
| PATENT CLAIMS |
Claim 1 A method of delaying transplant rejection in a subject comprising adm to subject a pharma compn comprising carrier or excipient & - Syalylated CR1 glycoprotein molecules, in which said compn exhibits dominant isoforms of sCR1 gp molecules which have an isoelectric point pI < 5.1 as determined by chromatofocusing & wherein pI of said isoforms increases after neuraminidase treat Claim 12 A method for making an sCR1 gp prepn comprising - Expressing DNA coding an sCR1 protein in a mammalian host cell in culture under conditions wherein cell growth is not limited by nutrient supply & wherein said host cell is ca pable of sialylation of oligosaccharide structures - Recovering a compn comprising a plurality of sCR1 gp molecules from the culture - Recovering sCR1 gp isoforms from the compn to afford a prepn which exhibits dominant sCR1 gp isoforms having pI < 5.1 as determined by chromatofocusing, wherein pI increases after neuraminidase treat sCR1 = Syalylated gp of soluble Complement Receptor 1 |
| PATENT PHOTOCOPY | Available on request |
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