| PATENT CLAIMS |
A method of stimulating the immune system comprising adm an immuno-stimulatory amount of an Ab raised against an antigen selected from: LAG-3; soluble protein fractions consisting of at least one of the 4 immunoglobulin type extracellular domains of the LAG-3 protein (AA 1-149, 150-239, 240-330 & 331-412 of SEQ ID NO:1); a substituted LAG-3 or substituted immunoglobulin type extracellular domain of LAG-3 consisting of AA residues 1-149, where one or more Arg residues at positions 73, 75 & 76 of SEQ ID NO:1 are substituted with Glu
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