| PATENT ASSIGNEE'S COUNTRY | USA |
| UPDATE | 03.00 |
| PATENT ASSIGNEE | Albert Einstein College of Medicine of Yeshiva University |
| PATENT CLAIMS |
- Obtaining an extract of a non-human model, wherein said extract contains at least one substrate that binds to carboxy peptidase E & said non-human model has an inactive ver sion of carboxypeptidase E resulting in accumulation of said substrate in said non-human model - Fractionating said extract on an affinity resin column, wherein the affinity resin of the column comprises a protein bound to solid support, & wherein said protein is selected from: anhydrotrypsin, inactive carboxypeptidase E having a point mutation in the AA seq of the carboxypeptidase E of Glu-342 to Gln-342, & carboxypeptidase E used in the presence of a thiol-directed inhibitor - Obtaining an elute fraction contg said substrate from said affinity column - Purifying & identifying said substrate contained in said elute fraction |
| PATENT PHOTOCOPY | Available on request |
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