| CLASSIFICATION | CommPat |
| PATENT ASSIGNEE'S COUNTRY | USA |
| TECHNOLOGY | Used to produce fully human Ab in mice |
| UPDATE | 06.00 |
| PATENT ASSIGNEE | This data is not available for free |
| PATENT CLAIMS |
Method for producing a transgenic mouse wherein the germ cells comprise at least one inactivated immunoglobulin heavy chain locus in which all of the J segment genes are deleted to prevent rearrangement of the locus & to prevent formation of a transcript of a rearranged locus & the expression of an endogenous immunoglobulin (Ab) heavy chain from the inactivated locus, said method comprising - Deleting the J segment genes from at least one endogeno us heavy chain locus in a mouse embryonic stem cell to prevent rearrangement of said locus & to prevent formation of a transcript of a rearranged immunoglobulin heavy chain locus, the deletion being effected by a targeting vector com prising a gene encoding a selectable marker & - Producing from the embryonic stem cell a transgenic mouse whose germ cells comprise at least one immuno globulin heavy chain locus in which all of the J segment genes are deleted |
| PATENT PHOTOCOPY | Available on request |
| TECHNOLOGY SOLD TO | This data is not available for free |
| TRADEMARK | This data is not available for free |
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