Main > HEPATOLOGY > Hepatitis GB Virus > Infection. Diagnostics > DNA Hybridization

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PATENT ASSIGNEE'S COUNTRY USA
UPDATE 04.00
PATENT ASSIGNEE This data is not available for free
PATENT CLAIMS Method for detecting target HGBV nucleic acid in test sample
- Reacting test sample with HGBV polynucleotide probe
comprising seq of > 15 contiguous nucleotides, wherein
said seq selectively hybridizes to genome of HGBV or its
full complement, wherein said HGBV comprises a positive
stranded RNA viral genome comprising an ORF encoding
a polyprotein, wherein said polyprotein (i) has AA seq
having > 35% identity to polyprotein seq selected from: SEQ
ID NO:387, 394 & 401 wherein said % identity is determined
by using the computer program GAP of the Wisconsin Pa
ckage, Version 8 with the gap penalty set to 3 & gap exten
sion penalty set to 0.1 & (ii) is not immunoreactive with an Ab
that specifically reacts with protein encoded by virus selec
ted from group: hepatitis A, B, C, Delta, & E virus, under con
ditions & for time which allows the formation of a complex
between probe & target HGBV nucleic acid in test sample
- Detecting the complex that contains the target HGBV nu
clic acid wherein the presence of complex is indicative
of presence of target HGBV
PATENT PHOTOCOPY Available on request

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