| PATENT ASSIGNEE'S COUNTRY | USA |
| UPDATE | 11.99 |
| PATENT ASSIGNEE | This data is not available for free |
| PATENT CLAIMS |
- Applying biol. fluid contg thrombopoietin to protein compri sing ligand-binding domain of an MPL receptor, which pro tein is bound to solid support, whereby said thrombopoie tin is adsorbed to said protein - Washing the protein to elute ybadsorbed material - Eluting the adsorbed thrombopoietin from said protein - Fractionating the eluted TPO by anion exchange chromato graphy & - Collecting the fractionated TPO; Wherein collected TPO is characterized by - MW 60000-80000 as determined by SDS-PAGE under denaturing conditions - > 90% pure with respect to contaminating proteins as deter mined by SDS-PAGE & Ag staining - Free of TPO species of MW < 55 kD - Stimulates MPL-dependent cell proliferation |
| PATENT PHOTOCOPY | Available on request |
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