| PATENT ASSIGNEE'S COUNTRY | USA |
| UPDATE | 11.99 |
| PATENT ASSIGNEE | This data is not available for free |
| PATENT CLAIMS |
Method for purifying thrombopoietin from biol. fluid - Applying biol. fluid contg thrombopoietin to a protein com prising ligand-binding domain of an MPL receptor, which protein is bound to solid support, whereby thrombopoietin is adsorbed to said protein - Washing protein to elute unadsorbed material - Eluting adsorbed thrombopoietin by anion exchange chro matography - Collecting the fractionated thrombopoietin Wherein the collected thrombopoietin is characterized by - MW 60000-80000 D as determined by SDS-PAGE under denaturing conditions - > 90% pure with respect to contaminating proteins as de termined by SDS-PAGE & Ag staining - Free of TPO species of MW < 55 kD - Stilumates MPL-dependent cell proliferation |
| PATENT PHOTOCOPY | Available on request |
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