Main > ENDOCRINOLOGY > Diabetes. Genetics > PPAR-Gama Gene Pathway > Diabetes Type II Risk Increase

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MECHANISM OF ACTION The researchers discovered that people with SNP variant of Gene PPAR-Gama has a 25% greater probability to develop diabetes type II. This susceptibility gene appears in 85% of population
The PPAR-Gama Gene affects the development of cells responsible for fat storage, controlling which will transform in adipose tissue. There had been always a belief of relationship between this gene & diabetes, but as majority of studies involved a small group of people, it was never possible to proof this thesis.
The new work involved 1,500 type II diabetics & 2,500 of their relatives
UPDATE 09.00
AUTHOR Altshuler David, Hirschhorn Joel, Lander Eric; Whitehead Institute for Biomedical Research
LITERATURE REF. This data is not available for free

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