Main > ORGANIC CHEMICALS > Amine > Solid Phase Prepn

Product USA. W

PATENT ASSIGNEE'S COUNTRY USA
UPDATE 08.99
PATENT ASSIGNEE Warner-Lambert
PATENT CLAIMS - Treat HO-(CH2)n-C(Me)2-OH (n = 2-5) with P-CH2-Cl (P =
styrene/divinylbenzene copolymer) in prsence of base &
solvent to afford (I)
- Treat (I) with 1,1'-carbonyldiimidazole in presence of base
& solvent to afford (II)
- Treat (II) seq with Me trifluoromethanesulfonate (MeOTf) &
tert amine base in solvent to afford in situ (III)
- Treat (III) to synthesize: P-CH2O-(CH2)n-C(Me)2-O-CO-Ami
ne (IV)
- Treat (IV) with acid in solvent to afford amine
PATENT PHOTOCOPY Available on request

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