Main > PROTEINS > Proteomics > Bacteria Proteomics > Pseudomonas > Exotoxin. Protein > Domain Ib. Replaced by > Disulfide-Stabilized Ab > Cancer Treat

Product USA. U

PATENT ASSIGNEE'S COUNTRY USA
UPDATE 06.00
PATENT ASSIGNEE This data is not available for free
PATENT CLAIMS Immunotoxin that does not require proteolytic activation for cytotoxic activity, said immunotoxin comprising
- Pseudomonas exotoxin (PE) having amino & carboxyl ter
minus, but lacking AA 1 to 279, & in which > half of domain Ib
is replaced with
- Part or all of either VL chain of Fv Ab fragment having amino
& carboxyl terminus or VH chain of Fv Ab fragment having
amino & carboxyl terminus, provided that if only a part of
VL or VH chain is used, said part specifically binds to
target molecule
PATENT PHOTOCOPY Available on request

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