| PATENT ASSIGNEE'S COUNTRY | USA |
| UPDATE | 06.99 |
| PATENT ASSIGNEE | USA - Dept of Health & Human Services |
| PATENT CLAIMS |
Method of diagnosing patient having deficiency in S-mephen ytoin 4'-hydroxylase activity - Obtaining sample of nucleic acid from patient - Analyzing a cytochrome P450 2C19 DNA seq from the nucleic acids in sample for presence of polymorphism indi cative of the deficiency - Wherein the polymorphism occurs at nucleotide 681 or 636 of the coding region of the P450 2C19 DNA genomic or cDNA seq - Wherein each nucleotide in coding region of the genomic seq is designated the same number as the corresponding nucleotide in the coding region of the cDNA seq in FIG 2, clone 11a (SEQ ID NO:2) when the genomic seq & cDNA seq are maximally aligned & the nucleotides in the coding region of the cDNA seq are assigned successive numbers starting of 1 for the A residue of the initiating methionine co don |
| PATENT PHOTOCOPY | Available on request |
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