| TECHNOLOGY |
Fluorescent probes that are excited by visible light have been shown to selectively detect Zn (II) cation at physiological pH. The compds are expected to offer a useful tool for measuring Zn(II) concn in living cells. To fashion the new probes (azacrownfluorone), the team designed & synthesized the fluorophore, coupling it directly to macrocyclic polyamine. Fluorescence is not affected by high concn of Na, K, Ca or Mg suggesting that the probes are specific for Zn |
| UPDATE | 03.00 |
| AUTHOR | Nagano Tetsuo; Prof of Molecular Pharmaceutics & Bioorganic Chemistry |
| LITERATURE REF. | Angew. Chem. Int. Ed., 39, p. 1052 (2000) |
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