| CORP. SALE |
Using X-ray crystallography, the researchers determined the structure of ARGINASE complexed with the INHIBITOR: - 2(S)-AMINO-6-BORONOHEXANOIC ACID (ABH) They found that the electron-deficient boron atom forms a tetrahedral boronate anion that bridges the binuclear Mn cluster. This binding mimics the tetrahedral intermediate formed during arginine hydrolysis & explains the inhibitor's tight binding & specificity |
| MECHANISM OF ACTION |
NO makes it possible for smooth muscle in penis to relax, allowing penis chambers to fill with blood. NO is synthesized in body by catalytic oxidation of L-Arginine Arginase catalytically hydrolyzes L-Arginine. With less L-Arginine available, less NO is produced. Arginase inhibitors would interfere with hydrolysis, leaving more L-arginine available for NO production. |
| OBSERVATION'S | The researchers tested ABH's potential to inhibit arginase, reporting that it did in fact, enhance the relaxation of IN VITRO samples of GI muscle tissue |
| UPDATE | 11.99 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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